DOCK8(DIDS) is described as:

Patients having recurrent ear & sinus infections, pneumonias, allergies, asthma, eczema, and recurrent viral skin infections such as shingles, molluscum, &  warts.  Elevated IgE levels, hypereosinophilia, low numbers of B & T cells, lymphopenia, low IgM levels, and variable IgG antibody responses are common. Cancers such as squamous cell carcinoma and lymphomas  are occurring frequently.

Diagnosis

 DOCK8 is an immunodeficiency syndrome(DIDS) caused by autosomal recessive loss of function mutations in the DOCK8 gene. This disease exists in many ethnic groups. Diagnosis is typically found by looking for the DOCK8 protein expression and sequencing of the gene. Only certain laboratories and research groups are capable of performing this test.

Treatment

Treating the symptoms is a priority. Monthly IVIG, antivirals, antibiotics, and antifungals are often administered. Multidisciplinary care is preferred with input from immunologists, dermatologists, infectious disease specialists, and ear, nose, throat specialists. CAT scans of the chest & sinus are performed as necessary. A curative treatment by hematopoietic cell transplantation is being researched.